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Scientific Concept and Goals

Cardiovascular disease (CVD) is the leading cause of death worldwide. According to the World Health Organization (WHO), at least half of the deaths and disabilities resulting from CVD could be avoided by improved primary or secondary prevention. Improved prevention of CVD requires a better understanding of the pathomechanisms and a faster and more efficient translation of novel leads into clinical application. Therefore, to effectively decrease CVD mortality, an integrated approach is needed that includes both prevention of the establishment of CVD via primary preventive measures and therapeutic targeting of established CVD with manifest vascular and myocardial damage.

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The mission of the Munich Heart Alliance is to accelerate the development of strategies to prevent and treat CVD. To fulfill this mission, we will focus on the following scientific objectives, each addressed by a distinct research program:

I) to identify, on a population level, risk factors predisposing to CVD
II) to model CVD in order to dissect the underlying mechanisms
III) to develop novel therapeutic strategies against CVD